用表达杂交III型蛋白的重组小肠结肠炎耶尔森菌进行口服疫苗接种可保护沙鼠免受阿米巴肝脓肿的侵害。
Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess.
作者信息
Lotter Hannelore, Rüssmann Holger, Heesemann Jürgen, Tannich Egbert
机构信息
Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany.
出版信息
Infect Immun. 2004 Dec;72(12):7318-21. doi: 10.1128/IAI.72.12.7318-7321.2004.
Abstract
Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.
摘要
通过口服表达与耶尔森氏菌外膜蛋白E（YopE）融合的溶组织内阿米巴半乳糖抑制性凝集素的减毒活小肠结肠炎耶尔森氏菌，在阿米巴肝脓肿沙鼠模型中实现了对侵袭性阿米巴病的保护。保护作用依赖于YopE转位结构域的存在，但与针对阿米巴凝集素的抗体反应无关。
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