用源自溶组织内阿米巴170千道尔顿表面粘附素的重组蛋白免疫沙土鼠以预防阿米巴肝脓肿
Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica.
作者信息
Zhang T, Stanley S L
机构信息
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Infect Immun. 1994 Jun;62(6):2605-8. doi: 10.1128/iai.62.6.2605-2608.1994.
Abstract
The protozoan parasite Entamoeba histolytica causes extensive morbidity and mortality worldwide through intestinal infection and amebic liver abscess. Here we show that vaccination of gerbils, a standard model for amebic liver abscess, with recombinant proteins derived from the 170-kDa galactose-binding adhesin of E. histolytica and the serine-rich E. histolytica protein or a combination of the two recombinant antigens provides excellent protection against subsequent hepatic challenge with virulent E. histolytica trophozoites.
摘要
原生动物寄生虫溶组织内阿米巴通过肠道感染和阿米巴肝脓肿在全球范围内导致广泛的发病和死亡。在此我们表明，用源自溶组织内阿米巴170 kDa半乳糖结合粘附素和富含丝氨酸的溶组织内阿米巴蛋白的重组蛋白或这两种重组抗原的组合对沙鼠（阿米巴肝脓肿的标准模型）进行疫苗接种，可提供出色的保护，使其免受随后强毒溶组织内阿米巴滋养体的肝脏攻击。
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Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica.用源自溶组织内阿米巴170千道尔顿表面粘附素的重组蛋白免疫沙土鼠以预防阿米巴肝脓肿
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本文引用的文献
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Protection of gerbils from amebic liver abscess by immunization with a recombinant Entamoeba histolytica antigen.用重组溶组织内阿米巴抗原免疫沙鼠以预防阿米巴肝脓肿
Infect Immun. 1994 Apr;62(4):1166-70. doi: 10.1128/iai.62.4.1166-1170.1994.
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Protection against amebic liver abscess in hamsters by means of immunization with amebic antigen and some of its fractions.通过用阿米巴抗原及其部分组分进行免疫来预防仓鼠的阿米巴肝脓肿。
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Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.介导溶组织内阿米巴体外黏附的半乳糖结合凝集素的分离。
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Vaccination of rabbits against Entamoeba histolytica with aqueous suspensions of trehalose-dimycolate as the adjuvant.以海藻糖二霉菌酸酯水悬浮液为佐剂对兔子进行抗溶组织内阿米巴疫苗接种。
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[Induction of protective antiamebic immunity in hamsters with heterologous antigens].[用异源抗原诱导仓鼠产生保护性抗阿米巴免疫]
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Entamoeba histolytica: from adherence to enteropathy.溶组织内阿米巴：从黏附到肠病
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