Novopashina D S, Sinyakov A N, Ryabinin V A, Venyaminova A G, Perrouault L, Brunet E, Giovannangeli C, Boutorine A S
Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.
Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(6-7):1015-22. doi: 10.1081/NCN-200026058.
Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.
本文描述了新型嘧啶寡聚（2'-O-甲基核糖核苷酸）与寡羧酰胺小沟结合剂（MGB）和苯并吲哚喹啉嵌入剂（BIQ）共轭物的设计、合成、物理化学及体外生物学研究。这些共轭物与目标双链DNA形成稳定的三链螺旋，并在结合后抑制其体外转录。
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