Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders as new sequence-specific agents recognizing both grooves of double-stranded DNA.
作者信息
Novopashina D, Sinyakov A, Ryabinin V, Venyaminova A, Boutorine A
机构信息
Novosibirsk Institute of Bioorganic Chemistry SB RAS, Novosibirsk, Russia.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1179-82. doi: 10.1081/NCN-120022830.
PMID:14565374
Abstract
Design, synthesis and physico-chemical studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with one or two oligo(pyrrolecarboxamide) minor groove binders (MGB) are described.
摘要
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