Tanamai Jaivan, Veeramanomai Sornchai, Indrakosas Nisa
Department of Medicine, Lerdsin Hospital, Bangruk, Bangkok 10500, Thailand.
J Med Assoc Thai. 2004 Oct;87(10):1156-61.
The present study aimed at investigating the cholesterol-lowering and side effects of garlic enteric coated tablets in comparison with placebo tablets. The study is a randomized double-blinded crossover design involving 116 volunteers. However, 16 of them did not complete the study. The remaining 100 volunteers were divided into two groups: 45 were in the trial group and the remaining 55 in the control group. The volunteers in the trial group were asked to take garlic tablets in the first three months, placebo in the second three months and discontinue all tablets in the last three months, while the volunteers in the control group started with three months of placebo followed by three months of garlic tablets and ended up with three months of tablets discontinuity. The results showed that there were no significant differences in the total serum cholesterol levels between the two groups at the end of three months or six months of the study. Side effects included headache, itching and complaints of garlic smell. No serious side effects relating to liver, kidney functions or hematologic side effects were detected
本研究旨在调查大蒜肠溶片与安慰剂片相比的降胆固醇作用及副作用。该研究采用随机双盲交叉设计，涉及116名志愿者。然而，其中16人未完成研究。其余100名志愿者分为两组：45人在试验组，其余55人在对照组。试验组的志愿者被要求在前三个月服用大蒜片，中间三个月服用安慰剂，最后三个月停止服用所有片剂，而对照组的志愿者先服用三个月安慰剂，接着服用三个月大蒜片，最后三个月停止服用片剂。结果显示，在研究的三个月末和六个月末，两组的血清总胆固醇水平无显著差异。副作用包括头痛、瘙痒和大蒜气味的不适。未检测到与肝肾功能或血液学相关的严重副作用。
