Sobenin Igor A, Nedosugova Lyudmila V, Filatova Lyudmila V, Balabolkin Mikhail I, Gorchakova Tatiana V, Orekhov Alexander N
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Acta Diabetol. 2008 Mar;45(1):1-6. doi: 10.1007/s00592-007-0011-x. Epub 2007 Sep 6.
Late complications in type 2 diabetic patients are commonly associated with accelerated development of atherosclerosis. In type 2 diabetes mellitus, non-enzymatic glycosylation of apo-B that is a function of hyperglycaemia is an efficient biochemical way of low-density lipoprotein atherogenic modification. So, proper metabolic control is needed to prevent late complications of diabetes. The study was performed to estimate the effects of time-released garlic powder tablet Allicor on the parameters of metabolic control and plasma lipids in type 2 diabetes mellitus. The metabolic action of Allicor was investigated in the 4-week double-blinded placebo-controlled study in 60 type 2 diabetic patients. Fasting blood glucose was measured daily, and serum fructosamine as well as cholesterol and triglyceride levels were determined at the baseline, after 1, 2, 3 and 4 weeks. It has been demonstrated that treatment with Allicor resulted in better metabolic control due to the lowering of fasting blood glucose, serum fructosamine and serum triglyceride levels. The results of this study may allow recommending garlic powder tablets Allicor for the treatment of type 2 diabetes mellitus along with dietary treatment and/or sulfonylurea derivatives to achieve better metabolic control. The benefits from garlic preparations may lead to the reduction of cardiovascular risk in diabetic patients.
2型糖尿病患者的晚期并发症通常与动脉粥样硬化的加速发展有关。在2型糖尿病中，载脂蛋白B的非酶糖基化是高血糖的一种作用，是低密度脂蛋白致动脉粥样硬化修饰的一种有效生化方式。因此，需要适当的代谢控制来预防糖尿病的晚期并发症。本研究旨在评估缓释大蒜粉片Allicor对2型糖尿病患者代谢控制参数和血脂的影响。在一项针对60名2型糖尿病患者的为期4周的双盲安慰剂对照研究中，对Allicor的代谢作用进行了研究。每天测量空腹血糖，并在基线、第1、2、3和4周后测定血清果糖胺以及胆固醇和甘油三酯水平。结果表明，服用Allicor进行治疗可降低空腹血糖、血清果糖胺和血清甘油三酯水平，从而实现更好的代谢控制。这项研究的结果可能有助于推荐大蒜粉片Allicor与饮食治疗和/或磺脲类衍生物一起用于治疗2型糖尿病，以实现更好的代谢控制。大蒜制剂的益处可能会降低糖尿病患者的心血管风险。
