关于非上位性选择的意义。

On the meaning of non-epistatic selection.

作者信息

Puniyani Amit, Liberman Uri, Feldman Marcus W

机构信息

Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

出版信息

Theor Popul Biol. 2004 Dec;66(4):317-21. doi: 10.1016/j.tpb.2004.05.001.

DOI:10.1016/j.tpb.2004.05.001

PMID:15560910

Abstract

In population genetics, the additive and multiplicative viability models are often used for the quantitative description of models in which the genetic contributions of several different loci are independent; that is, there is no epistasis. Non-epistasis may also be quantitatively defined in terms of measures of interaction used widely in statistics. Setting these measures of epistasis to zero yields alternative definitions of non-epistasis. We show here that these two definitions of non-epistasis are equivalent; that is, in the most general case of a multilocus, multiallele system, the additive and multiplicative viability models are unique solutions of the additive and multiplicative conditions, respectively, for non-epistasis.

摘要

在群体遗传学中，加性和乘性生存力模型常被用于定量描述多个不同基因座的遗传贡献相互独立的模型；也就是说，不存在上位性。非上位性也可以根据统计学中广泛使用的相互作用度量进行定量定义。将这些上位性度量设为零可得到非上位性的替代定义。我们在此表明，这两种非上位性定义是等价的；也就是说，在多基因座、多等位基因系统的最一般情况下，加性和乘性生存力模型分别是非上位性加性条件和乘性条件的唯一解。