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非体外循环冠状动脉搭桥手术及全动脉搭桥:曼谷心脏研究所的经验总结

Off-pump coronary bypass surgery and all arterial conduits: learning experience at Bangkok Heart Institute.

作者信息

Visudharom Kitipan, Jotisakulratana Vibul, Pitiguagool Vitoon, Banyatpiyaphod Sujit, Pamornsing Piyapan, Cumpeeravut Pranom

机构信息

Bangkok Heart Institute, Bangkok Hospital, Bangkok 10320, Thailand.

出版信息

J Med Assoc Thai. 2003 May;86 Suppl 1:S17-22.

Abstract

Off-pump coronary artery bypass technique or bypass graft surgery without the use of a heart-lung machine has been introduced in the last six years, and now comprises approximately 25 per cent of all coronary artery bypass surgery being done in the world. One of the goals of beating heart surgery is to eliminate the complications associated with the use of cardiopulmonary bypass. The use of all arterial conduits for coronary artery bypass graft has become more acceptable after experiences gained and reports of better long-term results. From January 2001 to December 21 2002 the authors performed 251 off-pump procedures. One hundred and nine of these cases were done utilizing all arterial conduits. The data was stratified using the US National Society of Thoracic Surgeons Cardiac Surgery Database pre-operative risk module and divided into 3 groups as suggested: Low risk group with a predicted mortality of 0-1 per cent (2 patients); Medium risk group with a predicted mortality of 2-9 per cent (87 patients), and High risk group with a predicted mortality of 10+ per cent (10 patients). The predicted mortality of the entire group was 4.5 per cent. There were 90 males and 19 females with a mean age of 60.2 +/- 10.7 years, with 15.6 per cent of them older than 70 years. Pre-operative co-morbidities included 1/4 of the patients who had ejection fraction (EF) of equal to or less than 0.4, 4.5 per cent had unstable angina, 1.6 per cent had urgent/emergent status, 26.6 per cent underwent re-operative procedure, 1 per cent had pre-operative serum creatinine more than 2 mg per cent, 4.8 per cent had a history of stroke, 20.2 per cent had a history of congestive heart failure, 45.2 per cent had a history of previous myocardial infarction, 10.7 per cent had a history of chronic obstructive pulmonary disease, 46.9 per cent had a history of diabetes, 62 per cent had hypertension, and 20 patients (18.3%) required intra aortic balloon pump. Intra-operative parameters revealed 3.7 +/- 1.3 grafts/patient. The left internal mammary artery (LIMA) was used to the left anterior descending (LAD) in 6.4 per cent, or sequential with the diagonals 93.6 per cent. The 30 days mortality was 3.6 per cent (4 cases). Further analysis revealed that pre-operatively, none of these 4 cases was in the low predicted (predicted mortality of 0-1%) risk group, 2 of them were in the medium (predicted mortality of 2-9%) and the other 2 were in the high predicted risk (predicted mortality of 10+%) group. The skin-to-skin time was 4.1 hours and there were two conversions to on-pump in this group. Post-operatively, the intubation time was 4.7 hours. There was no peri-operative myocardial infarction, one patient required dialysis, and no patient experienced stroke. There was no sternal wound or arm wound infection, 9.5 per cent experienced temporal sensation impairment at the site of the radial artery harvesting at one month. Re-operation for bleeding occurred in 3 cases, and thirteen patients (14.3%) developed new atrial fibrillation. The authors are no longer making a one-foot long incision and spread ten inches wide like in the old days'. With the less invasive approach lessened in the recent past, the authors have found the less invasive the incision the less the pain after surgery. Totally eliminating the leg incision has allowed the patient to get up and mobilize on the same afternoon, if the procedure was done in the morning. All of these approaches combined with the off-pump technique, as far as the authors are concerned, will provide those who need coronary arterial bypass graft the best operative procedure.

摘要

非体外循环冠状动脉搭桥技术,即不使用心肺机的搭桥移植手术,在过去六年中已被引入,目前约占全球所有冠状动脉搭桥手术的25%。心脏不停跳手术的目标之一是消除与使用体外循环相关的并发症。随着经验的积累以及长期效果更佳的报告出现,使用全动脉血管进行冠状动脉搭桥移植变得更易被接受。从2001年1月至2002年12月21日,作者进行了251例非体外循环手术。其中109例使用了全动脉血管。数据采用美国胸外科医师协会心脏手术数据库术前风险模块进行分层,并按建议分为3组:预测死亡率为0 - 1%的低风险组(2例患者);预测死亡率为2 - 9%的中风险组(87例患者);预测死亡率为10%及以上的高风险组(10例患者)。整个组的预测死亡率为4.5%。有90名男性和19名女性,平均年龄为60.2±10.7岁,其中15.6%的患者年龄超过70岁。术前合并症包括四分之一的患者射血分数(EF)等于或小于0.4,4.5%的患者患有不稳定型心绞痛,1.6%的患者处于紧急/急诊状态,26.6%的患者接受过再次手术,1%的患者术前血清肌酐超过2mg%,4.8%的患者有中风病史,20.2%的患者有充血性心力衰竭病史,45.2%的患者有既往心肌梗死病史,10.7%的患者有慢性阻塞性肺疾病病史,46.9%的患者有糖尿病病史,62%的患者有高血压,20例患者(18.3%)需要主动脉内球囊反搏。术中参数显示每位患者平均移植血管数为3.7±1.3根。左乳内动脉(LIMA)用于左前降支(LAD)的占6.4%,或与对角支序贯使用的占93.6%。30天死亡率为3.6%(4例)。进一步分析显示,术前这4例患者均不在低预测(预测死亡率为0 - 1%)风险组,其中2例在中风险组(预测死亡率为2 - 9%),另外2例在高预测风险组(预测死亡率为10%及以上)。皮肤到皮肤的手术时间为4.1小时,该组中有2例转为体外循环手术。术后,插管时间为4.7小时。围手术期无心肌梗死发生,1例患者需要透析,无患者发生中风。无胸骨伤口或手臂伤口感染,9.5%的患者在桡动脉取材部位术后1个月出现颞部感觉障碍。3例患者因出血需要再次手术,13例患者(14.3%)出现新发房颤。作者不再像过去那样做一英尺长、十英寸宽的切口。随着近年来手术切口侵入性降低,作者发现切口侵入性越小,术后疼痛越轻。完全消除腿部切口后,如果手术在上午进行,患者当天下午就能起床活动。就作者而言,所有这些方法与非体外循环技术相结合,将为那些需要冠状动脉搭桥移植的患者提供最佳的手术方式。

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