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饮食中的咖啡因、睡眠限制及实验室应激的血流动力学效应

Hemodynamic effects of dietary caffeine, sleep restriction, and laboratory stress.

作者信息

James Jack E, Gregg M Elizabeth

机构信息

Department of Psychology, National University of Ireland, Galway, Ireland.

出版信息

Psychophysiology. 2004 Nov;41(6):914-23. doi: 10.1111/j.1469-8986.2004.00248.x.

Abstract

This study examined the separate and interactive effects of caffeine, sleep restriction, and task-induced laboratory stress in 96 healthy male and female volunteers. Participants alternated weekly between ingesting placebo and caffeine (1.75 mg/kg) three times daily for 4 consecutive weeks, while being either rested or sleep restricted. Finapres measurements of blood pressure, cardiac output, and total peripheral resistance showed that caffeine produced persistent blood pressure increases with a vascular hemodynamic profile. Sleep restriction produced a pronounced vascular response not associated with appreciable changes in blood pressure, whereas blood pressure increases induced by cognitive activity showed mixed cardiac and vascular responses. The findings suggest that life-long dietary caffeine may contribute significantly to the development of cardiovascular disease.

摘要

本研究调查了咖啡因、睡眠限制和任务诱导的实验室压力对96名健康男性和女性志愿者的单独及交互作用。参与者连续4周每周交替服用安慰剂和咖啡因(1.75毫克/千克),每日3次,期间处于休息或睡眠受限状态。通过Finapres测量血压、心输出量和总外周阻力发现,咖啡因会导致血压持续升高,并伴有血管血液动力学特征。睡眠限制会产生明显的血管反应,但与血压的显著变化无关,而认知活动引起的血压升高则表现出心脏和血管反应的混合。研究结果表明,长期饮食中的咖啡因可能对心血管疾病的发展有显著影响。

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