Killgore William D S, Muckle Alison E, Grugle Nancy L, Killgore Desiree B, Balkin Thomas J
Department of Behavioral Biology, Walter Reed Army Institute of Research, Belmont, MA, USA.
Int J Neurosci. 2008 Nov;118(11):1547-57. doi: 10.1080/00207450802323970.
Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization. The effectiveness of caffeine, modafinil, dextroamphetamine, or placebo for sustaining performance on the Biber Cognitive Estimation Test (BCET) was compared in 29 men and 25 women following 46 hr of sleep deprivation. Stimulants had differential effects on BCET performance as a function of the sex of the subjects. Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men and women.
兴奋剂药物可在睡眠不足时恢复基本的警觉性，但尚不清楚它们如何影响复杂的执行功能，尤其是考虑到大脑结构存在性别差异的情况下。在29名男性和25名女性经历46小时睡眠剥夺后，比较了咖啡因、莫达非尼、右旋苯丙胺或安慰剂在维持比伯认知评估测试（BCET）表现方面的有效性。兴奋剂对BCET表现的影响因受试者性别而异。接受安慰剂或咖啡因的女性得分显著低于男性，而莫达非尼和右旋苯丙胺在维持男性和女性的BCET表现方面均有效。
