Hefny Ashraf F, Bashir Masoud O, Joshi Sandhya, Branicki Frank J, Abu-Zidan Fikri M
Department of Surgery, Al-Ain Hospital, Al-Ain, United Arab Emirates.
Asian J Surg. 2004 Oct;27(4):339-41. doi: 10.1016/S1015-9584(09)60064-6.
We report a case of a 36-year-old lady who presented with a huge fungating tumour that involved the entire right breast. The tumour was diagnosed histologically as undifferentiated primary stromal tumour of the breast with axillary lymph node metastasis. We review the literature of this rare malignant tumour. Stromal sarcomas of the breast lack epithelial participation, and diagnosis of these tumours can be difficult. Genome-wide expression profiling is currently used to determine the cell of origin of most sarcomas. Surgery offers the best therapeutic option. Adjuvant radiotherapy is not very beneficial, while chemotherapy has, to date, no established role in the management of this disease. The prognosis is dismal for patients with lymph node involvement. The size of the tumour has a lesser bearing on outcome.
我们报告一例36岁女性患者，其右乳出现一个巨大的溃疡性肿瘤，累及整个右乳。该肿瘤经组织学诊断为原发性乳腺未分化间质肿瘤伴腋窝淋巴结转移。我们回顾了关于这种罕见恶性肿瘤的文献。乳腺间质肉瘤缺乏上皮成分，这些肿瘤的诊断可能具有挑战性。目前，全基因组表达谱分析用于确定大多数肉瘤的起源细胞。手术是最佳治疗选择。辅助放疗益处不大，而化疗至今在该疾病的治疗中尚未确立作用。有淋巴结受累的患者预后不佳。肿瘤大小对预后的影响较小。
