ArrayExpress基因表达数据库：软件工程与实现视角
The ArrayExpress gene expression database: a software engineering and implementation perspective.
作者信息
Sarkans Ugis, Parkinson Helen, Lara Gonzalo Garcia, Oezcimen Ahmet, Sharma Anjan, Abeygunawardena Niran, Contrino Sergio, Holloway Ele, Rocca-Serra Philippe, Mukherjee Gaurab, Shojatalab Mohammadreza, Kapushesky Misha, Sansone Susanna-Assunta, Farne Anna, Rayner Tim, Brazma Alvis
机构信息
EMBL Outstation-Hinxton, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
出版信息
Bioinformatics. 2005 Apr 15;21(8):1495-501. doi: 10.1093/bioinformatics/bti157. Epub 2004 Nov 25.
MOTIVATION
The lack of microarray data management systems and databases is still one of the major problems faced by many life sciences laboratories. While developing the public repository for microarray data ArrayExpress we had to find novel solutions to many non-trivial software engineering problems. Our experience will be both relevant and useful for most bioinformaticians involved in developing information systems for a wide range of high-throughput technologies.
RESULTS
ArrayExpress has been online since February 2002, growing exponentially to well over 10,000 hybridizations (as of September 2004). It has been demonstrated that our chosen design and implementation works for databases aimed at storage, access and sharing of high-throughput data.
AVAILABILITY
The ArrayExpress database is available at http://www.ebi.ac.uk/arrayexpress/. The software is open source.
CONTACT
动机
许多生命科学实验室面临的主要问题之一仍然是缺乏微阵列数据管理系统和数据库。在开发微阵列数据公共知识库ArrayExpress时，我们不得不为许多复杂的软件工程问题寻找新颖的解决方案。我们的经验对于大多数参与为广泛的高通量技术开发信息系统的生物信息学家来说既相关又有用。
结果
ArrayExpress自2002年2月上线以来，呈指数级增长，截至2004年9月已超过10000次杂交。已经证明，我们选择的设计和实现适用于旨在存储、访问和共享高通量数据的数据库。
可用性
ArrayExpress数据库可在http://www.ebi.ac.uk/arrayexpress/获取。该软件是开源的。
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