在多次低剂量经阴道接种猿猴免疫缺陷病毒期间，短暂病毒血症和隐匿感染期先于持续性病毒血症和抗病毒免疫反应出现。
A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations.
作者信息
Ma Zhong-Min, Abel Kristina, Rourke Tracy, Wang Yichuan, Miller Christopher J
机构信息
California National Primate Research Center, University of California Davis, CA, USA.
出版信息
J Virol. 2004 Dec;78(24):14048-52. doi: 10.1128/JVI.78.24.14048-14052.2004.
Abstract
In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (10(3) 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.
摘要
在恒河猴中，经多次低剂量（10³ 50%组织培养感染剂量）经阴道（IVAG）接种猿猴免疫缺陷病毒（SIV）毒株SIVmac251后，出现了以持续性病毒血症和血清转化为特征的典型全身感染。猴子在多次低剂量经阴道暴露于SIVmac251后，经过不同次数的暴露出现了典型的SIV感染。一旦建立，全身感染与高剂量经阴道接种SIV后的SIV感染相同。然而，在多次经阴道暴露于SIV的系列过程早期，始终会出现以短暂的细胞相关或无细胞病毒血症为特征的隐匿性全身感染。此外，在低剂量经阴道SIV传播模型中，在典型全身感染建立之前就存在抗病毒细胞免疫反应。
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