病毒剂量和壬苯醇醚-9对恒河猴中猴免疫缺陷病毒生殖器传播的影响。
Effect of virus dose and nonoxynol-9 on the genital transmission of SIV in rhesus macaques.
作者信息
Miller C J, Alexander N J, Sutjipto S, Joye S M, Hendrickx A G, Jennings M, Marx P A
机构信息
California Primate Research Center, University of California, Davis.
出版信息
J Med Primatol. 1990;19(3-4):401-9.
One inoculation of cell-free SIVmac (50 TCID50) caused persistent viremia in nine of 13 female rhesus macaques inoculated intravaginally. Persistent viremia was produced in two of four male rhesus macaques by twice placing cell-free SIVMAC (50 TCID50) onto the skin and urethral os of the penis. Placing a spermicide containing nonoxynol-9 into the vaginal canal prior to repeated intravaginal inoculations of SIV prevented transmission of the virus in three of six female rhesus macaques.
单次接种无细胞SIVmac（50个半数组织培养感染剂量）可使13只经阴道接种的雌性恒河猴中的9只出现持续病毒血症。通过两次将无细胞SIVMAC（50个半数组织培养感染剂量）涂抹于4只雄性恒河猴阴茎的皮肤和尿道口，可使其中2只出现持续病毒血症。在重复经阴道接种SIV之前，向阴道内放置含壬苯醇醚-9的杀精剂可防止6只雌性恒河猴中的3只感染该病毒。
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