Hara Masahide, Saikawa Tetsunori, Kurokawa Mamoru, Sakata Toshiie, Yoshimatsu Hironobu
Internal Medicine I, School of Medicine, Oita University, Oita-gun, Oita, Japan.
Circ J. 2004 Dec;68(12):1173-8. doi: 10.1253/circj.68.1173.
Visceral fat is related to coronary atherosclerosis, but little is known about the relation between coronary atherosclerosis and percent body fat accumulated in different parts of the body.
The subjects were 100 consecutive patients with demonstrated electrocardiographic ischemic changes. Coronary atherosclerosis was assessed using Gensini's coronary score (CS), and for body fat distribution dual energy X-ray absorptiometry was used. The parameters measured were serum lipid concentrations, body weight, body mass index, percent total fat, trunk fat percent, arm fat percent and leg fat percent. Trunk fat percent correlated significantly with CS (p<0.01), and concentrations of low-density lipoprotein cholesterol (LDL-C) (p<0.01) and very low-density lipoprotein cholesterol (VLDL-C) (p<0.05) in men and women. Leg fat percent correlated negatively with CS in both men and women (p<0.01 for each). Concentrations of both LDL-C and VLDL-C correlated positively with CS in both men and women (p<0.01).
There is a difference between the effect of body fat in the legs and the trunk that suggests leg fat has an anti-atherosclerotic effect and a negative correlation with CS, and conversely, that trunk fat has a pro-atherosclerotic effect and correlates positively with CS.
内脏脂肪与冠状动脉粥样硬化有关，但关于冠状动脉粥样硬化与身体不同部位累积的体脂百分比之间的关系，人们知之甚少。
研究对象为连续100例有心电图缺血性改变的患者。采用Gensini冠状动脉评分（CS）评估冠状动脉粥样硬化情况，并使用双能X线吸收法测量体脂分布。测量的参数包括血脂浓度、体重、体重指数、总脂肪百分比、躯干脂肪百分比、手臂脂肪百分比和腿部脂肪百分比。躯干脂肪百分比与CS显著相关（p<0.01），在男性和女性中与低密度脂蛋白胆固醇（LDL-C）浓度（p<0.01）和极低密度脂蛋白胆固醇（VLDL-C）浓度（p<0.05）也显著相关。腿部脂肪百分比在男性和女性中均与CS呈负相关（男女均p<0.01）。LDL-C和VLDL-C浓度在男性和女性中均与CS呈正相关（p<0.01）。
腿部和躯干的体脂作用存在差异，提示腿部脂肪具有抗动脉粥样硬化作用且与CS呈负相关，相反，躯干脂肪具有促动脉粥样硬化作用且与CS呈正相关。
