Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine & Allied Sciences, Timarpur, New Delhi 110054, India.
Department of Endocrinology and Metabolism, Army Hospital (Research & Referral), Delhi Cantonment, New Delhi, India.
J Clin Densitom. 2013 Jul-Sep;16(3):353-359. doi: 10.1016/j.jocd.2012.08.074.
Obesity has been associated with increased bone mineral density (BMD). There is evidence of differential effect of regional fat on BMD. Hence, we undertook this study to evaluate the correlation between total body fat and its distribution with BMD in nonobese (mean body mass index: 25.0 ± 4.7 kg/m²) Indian adult volunteers. A total of 2347 participants (men: 39.4% and women: 60.6%) included in this cross-sectional study were divided according to sex and age. Fasting blood samples were drawn for biochemical parameters. Percent total body, truncal, and leg fat and BMD at lumbar spine, femur, and forearm were measured by dual-energy X-ray absorptiometry. The BMD at all sites (radius, femur, and spine) increased from lowest to highest quartiles of percent body fat. Percent truncal fat was positively correlated with BMD at all sites in both sexes, except for femoral neck in men, where it had negative correlation. Percent leg fat was positively related with BMD at all sites in premenopausal women, and spine and radius BMD in postmenopausal women. However, in men, it had negative correlation with femoral neck BMD. On multiple regression analysis, regional fat had positive association with BMD at all sites after adjusting for age, sex, lean mass index, 25-hydroxyvitamin D, and intact parathyroid hormone levels. Leg-to-total body fat ratio was negatively associated with BMD at all sites in men and pre- and postmenopausal women. Percent total body and regional fat have positive association with BMD at all sites in men and women.
肥胖与骨密度（BMD）增加有关。有证据表明，局部脂肪对 BMD 的影响存在差异。因此，我们进行了这项研究，以评估非肥胖（平均体重指数：25.0 ± 4.7 kg/m²）印度成年志愿者的全身脂肪及其分布与 BMD 的相关性。这项横断面研究共纳入 2347 名参与者（男性：39.4%，女性：60.6%），根据性别和年龄进行分组。抽取空腹血样检测生化参数。通过双能 X 射线吸收法测量全身、躯干和腿部脂肪百分比以及腰椎、股骨和前臂的 BMD。所有部位（桡骨、股骨和脊柱）的 BMD 均从体脂百分比最低到最高四分位数依次增加。躯干脂肪百分比与两性所有部位的 BMD 均呈正相关，除了男性的股骨颈，其呈负相关。绝经前女性的腿部脂肪百分比与所有部位的 BMD 均呈正相关，绝经后女性的脊柱和桡骨 BMD 也呈正相关。然而，在男性中，它与股骨颈 BMD 呈负相关。在多元回归分析中，调整年龄、性别、瘦体重指数、25-羟维生素 D 和完整甲状旁腺激素水平后，局部脂肪与所有部位的 BMD 呈正相关。腿部脂肪与全身脂肪的比例与男性和绝经前及绝经后女性所有部位的 BMD 呈负相关。全身和局部脂肪百分比与男性和女性所有部位的 BMD 均呈正相关。
