用抗CD20单克隆抗体治疗系统性红斑狼疮。
Treatment of SLE with anti-CD20 monoclonal antibody.
作者信息
Looney R John, Anolik Jennifer, Sanz Iñaki
机构信息
Allergy Immunology, Rheumatology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
出版信息
Curr Dir Autoimmun. 2005;8:193-205. doi: 10.1159/000082104.
Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organ systems and characterized by anti-nuclear antibodies. While T cells and dendritic cells may play major roles in SLE, several lines of evidence strongly suggest a central role for B cells. This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab).
系统性红斑狼疮（SLE）是一种累及多个器官系统且以抗核抗体为特征的自身免疫性疾病。虽然T细胞和树突状细胞可能在SLE中起主要作用，但多项证据有力地表明B细胞起核心作用。本文将综述B细胞在人类SLE中的作用以及目前关于用抗CD20（利妥昔单抗）清除B细胞治疗SLE的现有数据。
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