Szigethy Eva, Whitton Sarah W, Levy-Warren Anna, DeMaso David Ray, Weisz John, Beardslee William R
Department of Psychiatry, Children's Hospital Boston, Boston, MA 02115, USA.
J Am Acad Child Adolesc Psychiatry. 2004 Dec;43(12):1469-77. doi: 10.1097/01.chi.0000142284.10574.1f.
To evaluate the safety and feasibility of cognitive-behavioral therapy (CBT) for depression in physically ill adolescents.
In an open trial, 11 adolescents (12-17 years) with inflammatory bowel disease and either major or minor depression underwent 12 sessions of a manual-based CBT enhanced by social skills, physical illness narrative, and family psychoeducation components. Standardized instruments assessed pre- to posttreatment changes in depression, physical health, global psychological functioning, and social functioning. Perceived helpfulness and satisfaction with CBT were assessed.
There were significant reductions in DSM-IV depression diagnoses and depressive symptoms and improvements in global psychological and social functioning. Adolescents' perceptions of their general health and physical functioning improved, although illness severity measures were unchanged. High subject satisfaction and helpfulness ratings for CBT were found along with no adverse events and high subject adherence.
A manual-based CBT approach adapted to treat depression in physically ill adolescents appears to be a safe, feasible, and promising intervention.
评估认知行为疗法（CBT）对身体患病青少年抑郁症的安全性和可行性。
在一项开放性试验中，11名患有炎症性肠病且患有重度或轻度抑郁症的青少年（12 - 17岁）接受了12节基于手册的CBT治疗，该治疗通过社交技能、身体疾病叙述和家庭心理教育内容得到强化。使用标准化工具评估治疗前至治疗后抑郁症、身体健康、整体心理功能和社会功能的变化。评估了对CBT的感知帮助程度和满意度。
DSM - IV抑郁症诊断和抑郁症状显著减少，整体心理和社会功能得到改善。青少年对其总体健康和身体功能的认知有所改善，尽管疾病严重程度指标未变。发现青少年对CBT的满意度和帮助程度评分较高，且无不良事件，治疗依从性高。
一种适用于治疗身体患病青少年抑郁症的基于手册的CBT方法似乎是一种安全、可行且有前景的干预措施。
