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Why are physicians so skeptical about positive randomized controlled clinical trials in critical care medicine?

作者信息

Villar Jesús, Pérez-Méndez Lina, Aguirre-Jaime Armando, Kacmarek Robert M

机构信息

Research Institute, Hospital Universitario N.S. de Candelaria, Carretera del Rosario s/n, Canary Islands, 38010, Santa Cruz de Tenerife, Spain.

出版信息

Intensive Care Med. 2005 Feb;31(2):196-204. doi: 10.1007/s00134-004-2519-7. Epub 2004 Nov 23.

DOI:10.1007/s00134-004-2519-7
PMID:15565357
Abstract
摘要

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Unsuccessful and Successful Clinical Trials in Acute Respiratory Distress Syndrome: Addressing Physiology-Based Gaps.急性呼吸窘迫综合征中失败与成功的临床试验：填补基于生理学的差距
Front Physiol. 2021 Nov 30;12:774025. doi: 10.3389/fphys.2021.774025. eCollection 2021.
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Lessons for successful study enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study.来自退伍军人事务部/国立卫生研究院急性肾衰竭试验网络研究的成功研究招募经验教训。
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