Kikano G E, Stange K C
Department of Family Medicine, University Hospitals of Cleveland, OH 44106.
J Fam Pract. 1992 Apr;34(4):498-500, 502, 504.
Lead poisoning is a common disease that, if not detected, can lead to developmental delay and other serious sequelae. We report the case of a child with retained intracranial lead pellets from a gunshot injury, in whom elevated blood lead levels were detected approximately 1 year after the injury. No environmental source of lead was found, and a twin sister living in the same dwelling had considerably lower lead levels. The patient's lead levels diminished after each of four courses of chelation, but rebounded each time to potentially toxic levels after termination of therapy. Physicians should be particularly alert in screening for elevated lead levels in children with retained bullet fragments. In patients in whom removal of the bullet fragments is impractical, the potential risks of long-term chelation therapy must be weighed against the risks of lead toxicity.
铅中毒是一种常见疾病,若未被检测出来,可能会导致发育迟缓及其他严重后遗症。我们报告一例因枪伤导致颅内残留铅弹丸的儿童病例,该患儿在受伤约1年后被检测出血铅水平升高。未发现环境铅源,且居住在同一住所的孪生姐妹铅水平明显较低。该患者在进行了四个疗程的螯合治疗后,铅水平均有所下降,但每次治疗结束后又反弹至潜在中毒水平。医生在筛查有残留子弹碎片的儿童血铅水平升高时应格外警惕。对于无法取出子弹碎片的患者,必须权衡长期螯合治疗的潜在风险与铅中毒的风险。