Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Erlangen-Nuremberg, Germany.
J Neural Transm (Vienna). 2004 Dec;111(12):1611-6. doi: 10.1007/s00702-004-0232-x.
Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = -3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients.
较高的血浆同型半胱氨酸浓度可影响外周血细胞中的基因组DNA甲基化。在本对照研究中，我们观察到酒精中毒患者的基因组DNA甲基化显著增加（10%）（t = -3.16，自由度 = 158，p = 0.002），这与他们升高的同型半胱氨酸水平显著相关（多元线性回归，p < 0.001）。由于DNA甲基化是基因表达调控中的一个重要表观遗传因素，这些发现可能对这些患者随后可能出现的表观遗传控制紊乱具有重要意义。
