Akkaya A, Ornek Z, Kaleli S
Department of Chest Diseases, Süleyman Demirel University, School of Medicine, Isparta, Turkey.
Asian Pac J Allergy Immunol. 2004 Jun-Sep;22(2-3):103-8.
This study was aimed to determine the rate of occupational asthma (OA) in workers at a rose extracting plant. Specific clinical tests of 52 workers, randomly chosen from four local rose extracting plants, were statistically compared with the test results of 30 local control subjects of similar age and sex as the plant workers, but who had never worked in such a plant. There were no significant differences in pulmonary function tests (FVC, FEV1, FEV1/FVC, PEFR) between the control and test groups. Significantly higher serum total IgE values (p < 0.0001) were observed for the test subjects (239.08+/-240 IU/ml) compared to the control subjects (81.33+/-61.45 IU/ml). There were also significant differences (p < 0.0001) in the number of eosinophils between the control and test groups, with corresponding mean values of 2.28+/-2.75% and 0.73+/-1.72%, respectively. A specifically prepared skin prick test using a rose allergen (Rosa domescena) was positive for 53.84% in the test subjects whereas only 5.33% positive test results were seen in the control group. We have demonstrated the involvement of Rosa domescena pollen in occupational allergy, through IgE-mediated hypersensitivity. It was concluded that the workers of a rose oil extracting plant are more susceptible to the rose pollens.
本研究旨在确定一家玫瑰提炼厂工人的职业性哮喘（OA）发病率。从当地四家玫瑰提炼厂随机选取52名工人进行特定临床测试，并将测试结果与30名年龄和性别与该厂工人相似、但从未在该厂工作过的当地对照对象的测试结果进行统计学比较。对照组和测试组在肺功能测试（FVC、FEV1、FEV1/FVC、PEFR）方面无显著差异。与对照组（81.33±61.45 IU/ml）相比，测试对象的血清总IgE值显著更高（p<0.0001）（239.08±240 IU/ml）。对照组和测试组之间的嗜酸性粒细胞数量也存在显著差异（p<0.0001），相应的平均值分别为2.28±2.75%和0.73±1.72%。使用玫瑰过敏原（百叶蔷薇）特制的皮肤点刺试验在测试对象中的阳性率为53.84%，而对照组的阳性测试结果仅为5.33%。我们已经通过IgE介导的超敏反应证明了百叶蔷薇花粉与职业性过敏有关。得出的结论是，玫瑰油提炼厂的工人更容易受到玫瑰花粉的影响。
