Unlü M, Sahin U, Yariktaş M, Demirci M, Akkaya A, Oztürk M, Orman A
Afyon Kocatepe University, School of Medicine, Department of Pulmonary Medicine, Süleyman Demirel University, Isparta, Turkey.
Asian Pac J Allergy Immunol. 2001 Dec;19(4):231-5.
After the diagnosis of allergic rhinitis due to Rosa domescena was suspected in one subject with skin prick and nasal provocation tests, we recruited all other workers employed in rose cultivation in Yakaören village, Isparta. From May 2000 to July 2000 (exposure period 'time of rose handling'), we studied 600 individuals employed in rose cultivation. A questionnaire was administered by a physician, and skin testing was done by a nurse on 75 individuals suffering from asthma and/or rhinitis. Sera from these 75 subjects were available for immunologic testing. The diagnosis of atopy against rose was based on the presence of work-related symptoms, positive skin prick test (SPT) with rose extracts, and positive RAST. While no subject reported asthmatic symptoms, twenty of them reported either rhino-conjunctivitis, rhinitis or both on exposure to Rosa domescena. Fourteen of these subjects had increased specific IgE levels to Rosa domescena. Eleven (78.5%) also had a positive skin reaction to Rosa domescena. Out of the six negative sera with normal specific IgE levels to rose, only two (33.3%) had positive skin reactivity. No subject had significant daily peak expiratoy flow rate (PEFR) variations. We conclude that exposure to Rosa domescena may represent a risk for allergic rhinitis. The possibility of an occupational rose allergy should therefore be taken into consideration in the subjects working in rose cultivation.
在一名受试者通过皮肤点刺试验和鼻激发试验被怀疑患有因多花蔷薇引起的过敏性鼻炎后，我们招募了伊斯帕尔塔亚卡ören村所有从事玫瑰种植的其他工人。从2000年5月到2000年7月（暴露期“接触玫瑰的时间”），我们对600名从事玫瑰种植的人员进行了研究。由一名医生发放问卷，一名护士对75名患有哮喘和/或鼻炎的人员进行皮肤测试。这75名受试者的血清可用于免疫学检测。对玫瑰的特应性诊断基于与工作相关的症状、玫瑰提取物皮肤点刺试验（SPT）阳性以及放射性变应原吸附试验（RAST）阳性。虽然没有受试者报告哮喘症状，但其中20人报告在接触多花蔷薇时出现鼻结膜炎、鼻炎或两者皆有。这些受试者中有14人对多花蔷薇的特异性IgE水平升高。其中11人（78.5%）对多花蔷薇的皮肤反应也呈阳性。在6份对玫瑰特异性IgE水平正常的阴性血清中，只有2份（33.3%）皮肤反应呈阳性。没有受试者的每日呼气峰值流速（PEFR）有显著变化。我们得出结论，接触多花蔷薇可能是过敏性鼻炎的一个风险因素。因此，在从事玫瑰种植的人员中应考虑职业性玫瑰过敏的可能性。
