Würfel W
Kinderwunschcentrum, München-Pasing.
MMW Fortschr Med. 2004 Oct 28;146(44):37, 39-40.
The use of epididymal or testicular sperm for ICSI should be employed only as a last resort to restore male reproductive function. Depending on whether the underlying cause of the infertility is obstructive or non-obstructive, prior appropriate genetic examinations are to be recommended. For the collection of sperm, microsurgical epididymal sperm aspiration (MESA) and TESE (testicular sperm extraction) are accepted methods. Today, cryopreservation of the sperm thus obtained is standard. In the event of obstructive causes, the pregnancy rate per treatment cycle is almost as high as with ICSI employing ejaculated spermatozoa. If existing genetic defects are excluded, congenital anomalies among the resulting children is presumably somewhat elevated in comparison with the normal population, although there are also studies that have failed to confirm this.
仅在恢复男性生殖功能的最后手段时才应使用附睾或睾丸精子进行卵胞浆内单精子注射（ICSI）。根据不育的潜在原因是梗阻性还是非梗阻性，建议事先进行适当的基因检查。对于精子采集，显微外科附睾精子抽吸术（MESA）和睾丸精子提取术（TESE）是被认可的方法。如今，对由此获得的精子进行冷冻保存是标准做法。在梗阻性原因的情况下，每个治疗周期的妊娠率几乎与使用射出精子进行ICSI时一样高。如果排除现有的基因缺陷，与正常人群相比，由此产生的儿童中先天性异常情况可能会有所升高，尽管也有研究未能证实这一点。
