医生参与制药公司赞助的临床试验和讲座的患病率及影响因素。

Prevalence and determinants of physician participation in conducting pharmaceutical-sponsored clinical trials and lectures.

作者信息

Ashar Bimal H, Miller Redonda G, Getz Kelly J, Powe Neil R

机构信息

Division of General Internal Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

J Gen Intern Med. 2004 Nov;19(11):1140-5. doi: 10.1111/j.1525-1497.2004.30414.x.

DOI:10.1111/j.1525-1497.2004.30414.x

PMID:15566444

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1494790/

Abstract

BACKGROUND

The relationship between physicians and the pharmaceutical industry is controversial because of the potential for conflicts of interest. However, little empirical evidence exists on the extent of physician participation in activities sponsored by pharmaceutical companies.

OBJECTIVES

To determine the prevalence of participation of internal medicine physicians in clinical trials and lectures sponsored by pharmaceutical companies and to describe factors that are associated with such participation.

DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional regional survey of 1,000 Maryland internal medicine physicians between February 2000 and January 2001 in order to measure the prevalence of physician participation in pharmaceutical-sponsored clinical trials and lectures. We also collected economic and demographic information to examine potential associations between physician characteristics and engagement in such activities.

RESULTS

Of 835 eligible physicians 444 (53%) responded, of whom 37% reported engaging in pharmaceutical-sponsored clinical trials and/or lectures to supplement their incomes. In our multivariable analysis, subspecialists versus generalist physicians (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.14 to 2.99), physicians in private group-single specialty and academic practice versus physicians in solo practice (OR, 2.30; 95% CI, 1.19 to 4.44 and OR, 2.56; 95% CI, 1.17 to 5.61, respectively), and physicians with higher versus lower annual incomes (OR, 1.22; 95% CI, 1.04 to 1.44) had a greater odds of participation in these activities. Additionally, physicians dissatisfied with their income had a 140% greater odds of participation (OR, 2.36; 95% CI, 1.45 to 3.83) than those who were satisfied with their income.

CONCLUSIONS

A substantial number of internists engage in pharmaceutical industry-sponsored clinical trials and/or lectures in an effort to supplement their incomes. Physician dissatisfaction with income appears to partially explain such participation.

摘要

背景

由于存在利益冲突的可能性，医生与制药行业之间的关系颇具争议。然而，关于医生参与制药公司赞助活动的程度，实证证据却很少。

目的

确定内科医生参与制药公司赞助的临床试验和讲座的普遍性，并描述与此类参与相关的因素。

设计、地点和参与者：2000年2月至2001年1月期间，我们对1000名马里兰州内科医生进行了一项横断面区域调查，以衡量医生参与制药公司赞助的临床试验和讲座的普遍性。我们还收集了经济和人口统计信息，以研究医生特征与参与此类活动之间的潜在关联。

结果

在835名符合条件的医生中，444名（53%）做出了回应，其中37%报告参与了制药公司赞助的临床试验和/或讲座以补贴收入。在我们的多变量分析中，专科医生与普通医生相比（优势比[OR]，1.85；95%置信区间[CI]，1.14至2.99），私人团体单一专科和学术机构的医生与个体执业医生相比（OR分别为2.30；95%CI，1.19至4.44和OR，2.56；95%CI，1.17至5.61），以及年收入较高与较低的医生（OR，1.22；95%CI，1.04至1.44）参与这些活动的几率更大。此外，对收入不满意的医生参与的几率比那些对收入满意（OR，2.36；95%CI，1.45至3.83）的医生高140%。