Burger Albert, Davidson Duncan, Yang Yiya, Baldock Richard
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
BMC Bioinformatics. 2004 Nov 26;5:184. doi: 10.1186/1471-2105-5-184.
Anatomy ontologies play an increasingly important role in developing integrated bioinformatics applications. One of the primary relationships between anatomical tissues represented in such ontologies is part-of. As there are a number of ways to divide up the anatomical structure of an organism, each may be represented by more than one valid partonomic (part-of) hierarchy. This raises the issue of how to represent and integrate multiple such hierarchies.
In this paper we describe a solution that is based on our work on an anatomy ontology for mouse embryo development, which is part of the Edinburgh Mouse Atlas Project (EMAP). The paper describes the basic conceptual aspects of our approach and discusses strengths and limitations of the proposed solution. A prototype was implemented in Prolog for evaluation purposes.
With the proposed name set approach, rather than having to standardise hierarchies, it is sufficient to agree on a suitable set of basic tissue terms and their meaning in order to facilitate the integration of multiple partonomic hierarchies.
解剖学本体在开发集成生物信息学应用中发挥着越来越重要的作用。此类本体中所表示的解剖组织之间的主要关系之一是“属于一部分”。由于存在多种划分生物体解剖结构的方式，每种方式可能由多个有效的部分论（属于一部分）层次结构表示。这就引发了如何表示和整合多个此类层次结构的问题。
在本文中，我们描述了一种基于我们在小鼠胚胎发育解剖学本体方面工作的解决方案，该本体是爱丁堡小鼠图谱计划（EMAP）的一部分。本文描述了我们方法的基本概念方面，并讨论了所提出解决方案的优缺点。为了评估目的，用Prolog实现了一个原型。
采用所提出的命名集方法，不必对层次结构进行标准化，只需就一组合适的基本组织术语及其含义达成一致，以便于整合多个部分论层次结构。
