Chen Chun-Lin, Sun Ming-Hui, Tan Dao-Cai, Liang Li-Zhi
Department of Obstetrics and Gynecology, The First Municipal People's Hospital of Guangzhou City, Guangzhou,Guangdong, 510180, P.R.China.
Ai Zheng. 2004 Nov;23(11 Suppl):1405-8.
BACKGROUND & OBJECTIVE: Transarterial chemoembolization, based on transarterial chemotherapy, is a new treatment for malignant neoplasms. This study was to investigate distribution of platinum (Pt) in blood and uterine tissue after infusing different carboplatin arterially.
Fourteen female dogs were randomly divided into 2 groups: embolizational group (group A, 7 dogs),and chemotherapy group (group B, 7 dogs). In group A, carboplatin (12 mg/kg), mingled with lipidol ultra-fluid (0.2 ml/kg), was injected into dogs' iliac arteries. In group B, carboplatin (12 mg/kg), dissolved in 5% glucose, was injected into the same arteries. The uterine tissues and blood samples were collected at different time points, concentrations of Pt in samples were measured by atomic absorption method.
Peak concentration of Pt in uterine tissues of group A was (215.0+/-17.6) microg/g, that of group B was (211.3+/-40.1) microg/g (P >0.05), the peak appeared at 0 min in both groups. Area under concentration-time curve (AUC) of Pt in tissues of group A was (13.9+/-3.9) mg x min x g(-1), significantly larger than that of group B (5.9+/-0.6) mg x min x g(-1). Peak concentration of Pt in plasma of group A was (8.7+/-12.5) microg/g, that of group B was (16.7+/-3.6) microg/g. AUC(0-240 min) was (0.5+/-0.1) mg x min x g(-1) in group A,and (1.2+/-0.4) mg x min x g(-1) in group B (P< 0.05).
Compared with arterial chemotherapy, arterial chemo- embolization may result in higher Pt concentration in local area, and lower Pt concentration in plasma, it may reduce the systemic toxicities, and enhance local effect on tumor.
经动脉化疗栓塞术基于经动脉化疗，是一种治疗恶性肿瘤的新方法。本研究旨在探讨经动脉注入不同剂量卡铂后铂（Pt）在血液及子宫组织中的分布情况。
14只雌性犬随机分为2组：栓塞组（A组，7只）和化疗组（B组，7只）。A组将卡铂（12mg/kg）与超液化碘油（0.2ml/kg）混合后注入犬髂动脉；B组将卡铂（12mg/kg）溶于5%葡萄糖中注入同一动脉。在不同时间点采集子宫组织和血样，采用原子吸收法测定样本中Pt浓度。
A组子宫组织中Pt的峰值浓度为（215.0±17.6）μg/g，B组为（211.3±40.1）μg/g（P>0.05），两组峰值均出现在0分钟。A组组织中Pt浓度-时间曲线下面积（AUC）为（13.9±3.9）mg·min·g⁻¹，显著大于B组（5.9±0.6）mg·min·g⁻¹。A组血浆中Pt的峰值浓度为（8.7±12.5）μg/g，B组为（16.7±3.6）μg/g。A组AUC（0 - 240分钟）为（0.5±0.1）mg·min·g⁻¹，B组为（1.2±0.4）mg·min·g⁻¹（P<0.05）。
与动脉化疗相比，动脉化疗栓塞术可使局部Pt浓度更高，血浆中Pt浓度更低，可能降低全身毒性，增强对肿瘤的局部作用。
