Pohlen Uwe, Rieger Hayo, Meyer Bernhard T, Loddenkemper Christoph, Buhr Heinz J, Heitland Peter, Koester Helmut D, Schneider Paul
Department of Surgery, Charité Campus Benjamin Franklin Medical Center, Hindenburgdamm 30, D-12200 Berlin, Germany.
Anticancer Res. 2007 Mar-Apr;27(2):809-15.
To improve tumor control in lung metastases using a novel method: unilateral chemoembolization of the lung by instillation of degradable starch microspheres (DSM) and cytotoxic agents via the pulmonal artery.
A rodent model of solitary metastasis (CC531 adenocarcinoma) was studied. The animals were randomized into three groups: the control group receiving carboplatin (45 mg/kg) intravenously, an isolated lung perfusion (ILP) group recieving buffered starch solution and carboplatin (15 mg/kg) and a third group receiving chemoembolization with carboplatin (15 mg/kg) and DSM (2 ml/kg). The total platinum concentration in serum, lung and lung tumor at defined times (15, 30, 60, 120 min) was measured using an inductively coupled plasma mass spectrometer (ICP-MS).
The area under concentration (AUC) versus time curves showed a 7.9- to 42.6-fold higher concentration in the tumor tissue comparing the ILP and chemoembolization group to the control group (p < 0.01). In the comparison of the AUCs of ILP versus chemoembolization, the tumor tissue of the lung showed a 5.4-fold higher concentration in the chemoembolization group (p < 0.01).
This is the first study to measure the concentration of carboplatin during chemoembolization of the lung. Compared to intravenous therapy, chemoembolization produced higher tumor tissue concentrations. Comparing chemoembolization to ILP, there was also an increase of carboplatin in the tumor tissue, without histological damage of the surrounding lung parenchyma.
采用一种新方法提高肺转移瘤的控制效果，即通过肺动脉注入可降解淀粉微球（DSM）和细胞毒性药物对肺进行单侧化疗栓塞。
研究了孤立转移（CC531腺癌）的啮齿动物模型。将动物随机分为三组：对照组静脉注射卡铂（45mg/kg）；孤立肺灌注（ILP）组接受缓冲淀粉溶液和卡铂（15mg/kg）；第三组接受卡铂（15mg/kg）和DSM（2ml/kg）的化疗栓塞。使用电感耦合等离子体质谱仪（ICP-MS）在规定时间（15、30、60、120分钟）测量血清、肺和肺肿瘤中的总铂浓度。
浓度-时间曲线下面积（AUC）显示，与对照组相比，ILP组和化疗栓塞组肿瘤组织中的浓度高7.9至42.6倍（p<0.01）。在比较ILP组和化疗栓塞组的AUC时，肺肿瘤组织在化疗栓塞组中的浓度高5.4倍（p<0.01）。
这是第一项测量肺化疗栓塞过程中卡铂浓度的研究。与静脉治疗相比，化疗栓塞产生了更高的肿瘤组织浓度。将化疗栓塞与ILP进行比较，肿瘤组织中的卡铂也有所增加，且周围肺实质无组织学损伤。
