Aso Nobuko, Tamura Akira, Nasu Masaru
Second Department of Internal Medicine, Oita University, Oita, Japan.
Am J Cardiol. 2004 Dec 1;94(11):1468-70. doi: 10.1016/j.amjcard.2004.07.156.
Circulating serum tenascin-C (an extracellular matrix glycoprotein) levels in patients with idiopathic dilated cardiomyopathy (IDC) were measured. Serum tenascin-C levels were increased in proportion to the severity of left ventricular dysfunction in patients with IDC. The associations of serum tenascin-C levels with serum troponin T and procollagen type III aminoterminal peptide levels suggest that increased levels of serum tenascin-C indicate ongoing replacement fibrosis after myocardial damage in IDC.
对特发性扩张型心肌病（IDC）患者的循环血清腱生蛋白-C（一种细胞外基质糖蛋白）水平进行了测量。IDC患者血清腱生蛋白-C水平与左心室功能障碍的严重程度成比例增加。血清腱生蛋白-C水平与血清肌钙蛋白T和III型前胶原氨基末端肽水平之间的关联表明，血清腱生蛋白-C水平升高表明IDC患者心肌损伤后存在持续的替代性纤维化。
