Zacchigna Marina, Di Luca Gabriella, Cateni Francesca, Maurich Venerando
Dipartimento di Scienze Farmaceutiche, Piazzale Europa 1, 34127 Trieste, Italy.
Eur J Pharm Sci. 2004 Dec;23(4-5):379-84. doi: 10.1016/j.ejps.2004.09.001.
One of the most used and useful polymers, poly(ethylene glycol) (PEG) was used as a carrier for warfarin. The drug-polymer conjugate was freely water soluble at room temperature. The hydrolytic stability of the PEG-warfarin was investigated at physiological pH and confirmed the stability of the conjugate. In vivo release studies demonstrated a good release of parent drug, without the initial high plasma level of warfarin.
