Parsa Andrew T, Holland Eric C
Department of Neurological Surgery, University of California San Francisco, CA 94143, USA.
Trends Mol Med. 2004 Dec;10(12):607-13. doi: 10.1016/j.molmed.2004.10.009.
Ras and Akt are signaling proteins that mediate fundamental aspects of normal growth and development in many organisms. When the Ras and Akt pathways become overly active, malignant transformation of normal tissue can occur. The combined activity of these two proteins has generated the transformation of human cell cultures and tumor formation in mice. In this review we highlight malignant glioma as a tumor type in which Ras and Akt pathways cooperate to cause tumorigenesis and regulate translation. The downstream components of these pathways have provided therapeutic targets that are currently being tested in clinical trials.
Ras和Akt是信号蛋白，介导许多生物体正常生长和发育的基本方面。当Ras和Akt信号通路过度活跃时，正常组织可能会发生恶性转化。这两种蛋白的联合活性已导致人类细胞培养物的转化和小鼠肿瘤的形成。在本综述中，我们重点介绍恶性胶质瘤这种肿瘤类型，其中Ras和Akt信号通路协同作用导致肿瘤发生并调节翻译。这些信号通路的下游成分提供了目前正在临床试验中进行测试的治疗靶点。
