一种基于界面溶剂交换的使用超声雾化器的新型微囊化方法。

A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange.

作者信息

Yeo Yoon, Park Kinam

机构信息

Department of Pharmaceutics, Purdue University, West Lafayette, IN 47907, USA.

出版信息

J Control Release. 2004 Dec 10;100(3):379-88. doi: 10.1016/j.jconrel.2004.09.012.

DOI:10.1016/j.jconrel.2004.09.012

PMID:15567503

Abstract

Reservoir-type microcapsules were produced in a mild and highly efficient manner using a coaxial ultrasonic atomizer. To understand the microencapsulation mechanism, the atomizer was operated in different modes. The results suggested the reservoir-type microcapsules were formed by midair collision of the microdrops of the two component liquids consisting of a polymer solution and an aqueous solution. The encapsulation efficiency and the distribution of the microdrops captured in midair were dependent on the ratio of the flow rates of the two liquids, which suggested that the collision involved multiple microdrops. This method allowed lysozyme to be encapsulated without loss of functional integrity and to be released with near zero-order kinetics for over 50 days. The ultrasonic atomizer provided a new method of preparing reservoir-type microcapsules.

摘要

采用同轴超声雾化器以温和且高效的方式制备了储库型微胶囊。为了解微胶囊化机制，对雾化器进行了不同模式的操作。结果表明，储库型微胶囊是由聚合物溶液和水溶液组成的两种组分液体的微滴在空气中碰撞形成的。包封效率和捕获在空气中的微滴分布取决于两种液体流速的比例，这表明碰撞涉及多个微滴。该方法可使溶菌酶在不损失功能完整性的情况下被包封，并以接近零级动力学的方式释放超过50天。超声雾化器提供了一种制备储库型微胶囊的新方法。