Zhang Yong-Hong, Chen Xin-Yue, Jiang Yan, Xiao Yao, Liu Zhen, Long Xiao-Shan, Wu Hao
Department of Infectious Diseases, You'an Hospital, Beijing 100054, China.
Hepatobiliary Pancreat Dis Int. 2004 Nov;3(4):538-42.
Co-infection of hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) is common in hemophiliacs and drug abusers. To assess the interaction between HIV and HCV disease progression, we examined 82 HIV/HCV co-infection patients and 62 HCV infection patients.
Liver function, pathological changes, infection duration, immune function and qualitative HCV-RNA and HCV antibody were compared retrospectively between the two groups of patients.
Fourty-eight patients (58.5%) in the HIV/HCV co-infection group and 53 patients (85.5%) in the HCV infection group showed abnormal liver function. No significant difference was observed in inflammation and fibrosis in the two groups (P=0.187, 0.954). However, liver abnormality in the patients with HIV/HCV co-infection appeared 8 years earlier than in those with HCV infection alone (P<0.001). As to immune function, the counts of CD+4 T and CD+8 T in the HIV/HCV group were (226.35+/-173.49)X10(6)/L and (914.40+/-448.28)X10(6)/L, whereas in the HCV group they were (752.31+/-251.69)X10(6)/L and (529.01+/-170.67)X10(6)/L respectively. The difference in the two groups was highly significant (P<0.001; P<0.001). The ratio of the number of people with both HCV-RNA and HCV antibody positive to the number of HCV-RNA positive and HCV antibody negative in the HIV/HCV group was 52:9, whereas in the HCV group it was 44:1 (P=0.043).
HIV/HCV co-infection can accelerate deterioration of hepatitis C, which may be due to the effect of HIV on cellular immunity and humoral immunity of the body.
丙型肝炎病毒（HCV）与1型人类免疫缺陷病毒（HIV-1）合并感染在血友病患者和药物滥用者中很常见。为评估HIV与HCV疾病进展之间的相互作用，我们对82例HIV/HCV合并感染患者和62例HCV感染患者进行了检查。
对两组患者的肝功能、病理变化、感染持续时间、免疫功能以及HCV-RNA定性和HCV抗体进行回顾性比较。
HIV/HCV合并感染组48例患者（58.5%）肝功能异常，HCV感染组53例患者（85.5%）肝功能异常。两组炎症和纤维化情况无显著差异（P=0.187，0.954）。然而，HIV/HCV合并感染患者肝脏异常出现时间比单纯HCV感染患者早8年（P<0.001）。关于免疫功能，HIV/HCV组CD+4 T细胞计数为（226.35±173.49）×10(6)/L，CD+8 T细胞计数为（914.40±448.28）×10(6)/L，而HCV组分别为（752.31±251.69）×10(6)/L和（529.01±170.67）×10(6)/L。两组差异极显著（P<0.001；P<0.001）。HIV/HCV组HCV-RNA和HCV抗体均阳性人数与HCV-RNA阳性但HCV抗体阴性人数之比为52:9，而HCV组为44:1（P=0.043））。
HIV/HCV合并感染可加速丙型肝炎恶化，这可能是由于HIV对机体细胞免疫和体液免疫的影响。
