Muravyov Alexei V, Yakusevich Vladimir V, Surovaya Larisa, Petrochenko Aleksandr
Department of Medicine and Biology, University of Yaroslavl, 150000 Yaroslavl, Russia.
Clin Hemorheol Microcirc. 2004;31(4):251-6.
This study was designed to examine changes of hemorheological parameters in patients with CHD and hypercholesterolaemia (wide range of plasma total cholesterol level from 5.6 to 9.8 mmol.l-1) subjected to lipid lowering therapy with statins (simvastatin, 10.0-20.0 mg/day, dosage was dependent on an initial level of total cholesterol). Twenty female subjects were enrolled in this research program. Both prior to and following drug treatment for eight weeks, hemorheological measurements included plasma viscosity, high and low shear whole blood viscosity, hematocrit, RBC aggregation and rigidity. Treatment with simvastatin significantly (p<0.05) reduced total cholesterol, total triglycerides and low-density lipoprotein cholesterol (LDL-C). However, the hemorheological effects of lipid lowering therapy differed markedly between macro- and microrheological groups of parameters: plasma and whole blood viscosity were not significantly changed whereas RBC aggregation and its rigidity were decreased significantly after statin treatment. These results thus suggest that the rheologic effect of lipid lowering therapy concerned mainly the microrheological parameters: red cell aggregation and deformability.
本研究旨在检测冠心病合并高胆固醇血症患者（血浆总胆固醇水平范围为5.6至9.8 mmol·l-1）接受他汀类药物（辛伐他汀，10.0 - 20.0 mg/天，剂量取决于总胆固醇初始水平）降脂治疗时血液流变学参数的变化。20名女性受试者参与了本研究项目。在药物治疗前及治疗八周后，血液流变学测量包括血浆粘度、高切和低切全血粘度、血细胞比容、红细胞聚集性和刚性。辛伐他汀治疗显著（p<0.05）降低了总胆固醇、总甘油三酯和低密度脂蛋白胆固醇（LDL-C）。然而，降脂治疗对宏观和微观血液流变学参数组的影响显著不同：血浆和全血粘度无显著变化，而他汀治疗后红细胞聚集性及其刚性显著降低。因此，这些结果表明降脂治疗的流变学效应主要涉及微观血液流变学参数：红细胞聚集性和变形性。
