血浆瘦素与乳腺癌风险：瑞典北部的一项前瞻性研究。

Plasma leptin and breast cancer risk: a prospective study in northern Sweden.

作者信息

Stattin Pär, Söderberg Stefan, Biessy Carine, Lenner Per, Hallmans Göran, Kaaks Rudolf, Olsson Tommy

机构信息

Department of Urology and Andrology, Umeå University Hospital, Umeå, Sweden.

出版信息

Breast Cancer Res Treat. 2004 Aug;86(3):191-6. doi: 10.1023/B:BREA.0000036782.11945.d7.

DOI:10.1023/B:BREA.0000036782.11945.d7

PMID:15567935

Abstract

INTRODUCTION

Obesity is associated with risk of breast cancer after menopause. Circulating levels of leptin are high in obesity and leptin stimulates growth of breast cancer cells.

MATERIAL AND METHODS

In a case-control study nested within the Northern Sweden Health and Disease Cohort, we measured leptin levels in prediagnostic plasma from 149 postmenopausal women who were diagnosed with breast cancer at a mean time 1.7 years (SD 2.0) after recruitment and among 258 control subjects.

RESULTS

No significant association between plasma levels of leptin and breast cancer risk was observed. Odds ratios (ORs) of breast cancer with increasing levels of leptin were 1.00 [referent], 1.01 [95% CI = 0.58-1.84], 0.65 [0.36-1.18], and 0.94 [0.53-1.67], and (p(for trend) = 0.54). Adjustment for smoking, body mass index, and plasma insulin did not affect risk estimates.

DISCUSSION

These data do not support the hypothesis that plasma leptin is a risk factor for breast cancer.

摘要

引言

肥胖与绝经后乳腺癌风险相关。肥胖人群中循环瘦素水平较高，且瘦素会刺激乳腺癌细胞生长。

材料与方法

在瑞典北部健康与疾病队列中的一项病例对照研究中，我们测量了149名绝经后女性在诊断为乳腺癌前的血浆瘦素水平，这些女性在入组后平均1.7年（标准差2.0）被诊断为乳腺癌，同时测量了258名对照者的血浆瘦素水平。

结果

未观察到血浆瘦素水平与乳腺癌风险之间存在显著关联。随着瘦素水平升高，乳腺癌的比值比（OR）分别为1.00（参照值）、1.01 [95%可信区间 = 0.58 - 1.84]、0.65 [0.36 - 1.18]和0.94 [0.53 - 1.67]，（趋势p值 = 0.54）。对吸烟、体重指数和血浆胰岛素进行校正后不影响风险估计值。