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乳腺癌患者循环瘦素浓度与基因多态性的关联：一项荟萃分析。

Association between circulating leptin concentration and gene polymorphism in patients with breast cancer: a meta-analysis.

作者信息

Hao Ji-Qing, Zhang Qian-Kun, Zhou Yi-Xin, Chen Li-Hao, Wu Peng-Fei

机构信息

Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Anhui, China.

出版信息

Arch Med Sci. 2019 Mar;15(2):275-283. doi: 10.5114/aoms.2018.75638. Epub 2018 May 15.

DOI:10.5114/aoms.2018.75638
PMID:30899280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6425221/
Abstract

INTRODUCTION

The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin gene polymorphisms and susceptibility to BC.

MATERIAL AND METHODS

Potentially relevant studies about serum/plasma leptin levels and leptin gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were assessed by the statistic and quantified using ; publication bias was qualitatively assessed by funnel plot and quantitatively assessed by Egger's linear regression test.

RESULTS

A total of 1141 articles were retrieved after database searches, and 27 studies with 9516 subjects (4542 BC patients/4974 controls) were finally included. The results indicated that BC patients had significantly higher leptin levels compared with healthy controls (SMD = 1.65, 95% CI: 1.21-2.09, < 0.001), but there was no association between leptin polymorphism and BC (OR = 1.05, 95% CI: 0.80-1.39, 0.722). Subgroup analyses demonstrated increased leptin levels in BC patients of different region, race, body mass index and waist circumference.

CONCLUSIONS

Our results revealed a significantly higher leptin level in BC patients than in healthy controls, but no association between leptin polymorphism and BC susceptibility was found.

摘要

引言

本荟萃分析的目的是总结乳腺癌（BC）患者血清/血浆瘦素浓度的证据，以及瘦素基因多态性与BC易感性之间的关联。

材料与方法

使用电子数据库PubMed、EMBASE和Cochrane图书馆（从1995年1月1日至2017年6月30日，无语言限制）选择关于血清/血浆瘦素水平和瘦素基因多态性的潜在相关研究。通过统计量评估异质性的潜在来源，并使用 进行量化；通过漏斗图定性评估发表偏倚，并通过Egger线性回归检验进行定量评估。

结果

数据库检索后共检索到1141篇文章，最终纳入27项研究，共9516名受试者（4542例BC患者/4974例对照）。结果表明，与健康对照相比，BC患者的瘦素水平显著更高（标准化均数差=1.65，95%可信区间：1.21-2.09，<0.001），但瘦素多态性与BC之间无关联（比值比=1.05，95%可信区间：0.80-1.39，=0.722）。亚组分析表明，不同地区、种族、体重指数和腰围的BC患者瘦素水平升高。

结论

我们的结果显示，BC患者的瘦素水平显著高于健康对照，但未发现瘦素多态性与BC易感性之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/a8ba2e168b8c/AMS-15-32753-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/84205d026cde/AMS-15-32753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/e81b2ee9eaf4/AMS-15-32753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/e32fd72d941b/AMS-15-32753-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/c041646e7d65/AMS-15-32753-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/a8ba2e168b8c/AMS-15-32753-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/84205d026cde/AMS-15-32753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/e81b2ee9eaf4/AMS-15-32753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/e32fd72d941b/AMS-15-32753-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/c041646e7d65/AMS-15-32753-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6820/6425221/a8ba2e168b8c/AMS-15-32753-g005.jpg

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