Goette A, Lendeckel U, Klein H U
Otto-von-Guericke-Universitätsklinik Magdeburg, Klinik für Kardiologie, Angiologie und Pneumologie, Leipziger Str. 44, 39120 Magdeburg, Germany.
Z Kardiol. 2004 Nov;93(11):864-77. doi: 10.1007/s00392-004-0147-4.
Atrial fibrillation (AF) is the most common clinical arrhythmia and one of the most important factors for embolic stroke. In recent years, a tremendous amount has been learned about the pathophysiology and molecular biology of AF. Thus, pharmacologic interference with specific signal transduction pathways appears promising as a novel antiarrhythmic approach to maintain sinus rhythm and to prevent atrial clot formation. This review highlights the underlying molecular biology of atrial fibrillation, which may also be relevant for AF therapy.
心房颤动（AF）是最常见的临床心律失常，也是导致栓塞性中风的最重要因素之一。近年来，人们对AF的病理生理学和分子生物学有了大量了解。因此，对特定信号转导通路进行药物干预作为一种维持窦性心律和预防心房血栓形成的新型抗心律失常方法，似乎很有前景。本综述重点介绍了心房颤动的潜在分子生物学，这可能也与AF治疗相关。
