Platzer M, Likar R, Stein C, Beubler E, Sittl R
Abteilung für Anästhesiologie und allgemeine Intensivmedizin, LKH Klagenfurt.
Schmerz. 2005 Aug;19(4):296-301. doi: 10.1007/s00482-004-0372-9.
The aim of this study was to demonstrate a peripheral local opioid effect using case examples involving inflammatory mucosal and cutaneous lesions.
A 0.1% morphine gel, mixed in the hospital pharmacy, was applied several times daily to inflammatory mucosal lesions (oral, anogenital and in one patient to a skin ulcer). The effects and side effects were documented.
All patients experienced a significant reduction in pain with the use of topical morphine gel and no side effects were seen.
Topical peripheral application of morphine gel is a simple, effective method that can be carried out by patients several times a day with few side effects.
本研究的目的是通过涉及炎性黏膜和皮肤病变的病例实例来证明外周局部阿片样物质的作用。
在医院药房配制的0.1%吗啡凝胶,每天多次应用于炎性黏膜病变(口腔、肛门生殖器,在一名患者中应用于皮肤溃疡)。记录其效果和副作用。
所有患者使用局部吗啡凝胶后疼痛均显著减轻,且未见副作用。
局部外用吗啡凝胶是一种简单、有效的方法,患者可每天自行操作数次,副作用少。