Bogdanova L P
Patol Fiziol Eksp Ter. 2004 Oct-Dec(4):19-21.
Pathophysiological mechanisms of the muscular tone was studied clinicoelectrophysiologically (the method of stimulating electromyography with evoked H-reflex) in 130 healthy subjects and 63 patients with dystonia musculorum deformans (23 patients of the latter were examined before and after intake of a therapeutic dose of L-DOPA). It was found that patients with impaired muscular tone have low activity of spinal motoneurons on both sides of the body especially the activity of phasic motoneurons and on the right side of the body. L-DOPA activates motoneurons, higher activation seen for the phasic motoneurons and on the right side of the body.
采用临床电生理学方法(诱发H反射的刺激肌电图法)对130名健康受试者和63例变形性肌张力障碍患者(其中23例患者在服用治疗剂量的左旋多巴前后进行了检查)的肌张力病理生理机制进行了研究。结果发现,肌张力受损患者身体两侧的脊髓运动神经元活性较低,尤其是相位运动神经元的活性以及身体右侧的活性。左旋多巴可激活运动神经元,相位运动神经元及身体右侧的激活程度更高。