Rose P G, Halter S A, Su C M
Department of Obstetrics and Gynecology, Ohio State University, Columbus.
J Surg Oncol. 1992 Apr;49(4):231-8. doi: 10.1002/jso.2930490406.
Radiation-induced intestinal injury is a dose limiting factor in the treatment of pelvic, abdominal, and retroperitoneal malignancies with radiation therapy. In experimental models, radiation has been associated with increased intestinal prostaglandin activity and in clinical trials prostaglandin inhibitors have been demonstrated to improve the symptoms of acute radiation enteritis. This study was conducted to determine if the prostaglandin inhibitor indomethacin could prevent the morphologic changes of acute radiation induced intestinal injury. Twenty-four male rats received either parenteral indomethacin at doses of 0.5, 1.0, and 3.0 mg/kg per dose every 12 hours or saline from 24 hours pre-radiation exposure until sacrifice 48 hours later. Twenty-four control animals received identical drug dosages and anesthesia but no radiation. Radiation produced a decreased villus/crypt ratio and increased acute inflammation and degeneration. Indomethacin treated animals demonstrated significantly less polymorphonuclear leukocyte infiltration and decreased degeneration. Villus/crypt ratio was not affected by indomethacin.
放射性肠损伤是盆腔、腹部和腹膜后恶性肿瘤放射治疗中的剂量限制因素。在实验模型中，辐射与肠道前列腺素活性增加有关，并且在临床试验中已证明前列腺素抑制剂可改善急性放射性肠炎的症状。本研究旨在确定前列腺素抑制剂吲哚美辛是否能预防急性放射性肠损伤的形态学变化。24只雄性大鼠从辐射暴露前24小时开始，每12小时接受一次剂量为0.5、1.0和3.0mg/kg的肠外吲哚美辛注射，或注射生理盐水，直至48小时后处死。24只对照动物接受相同的药物剂量和麻醉，但不接受辐射。辐射导致绒毛/隐窝比值降低，急性炎症和变性增加。吲哚美辛治疗的动物多形核白细胞浸润明显减少，变性减轻。绒毛/隐窝比值不受吲哚美辛影响。
