1,3-双（2-羟基亚氨基甲基吡啶鎓）丙烷作为被神经毒剂抑制的乙酰胆碱酯酶的潜在重活化剂。

1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents.

作者信息

Kuca Kamil, Dohnal Vlastimil

机构信息

Purkyne Medical Military Academy in Hradec Králové, Czech Republic: Department of Toxicology.

出版信息

Acta Medica (Hradec Kralove). 2004;47(3):167-9.

Abstract

The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator--pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10(-4) M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10(-1) M (for cyclosarin) and 10(-3) M (for VX) but these concentrations are not available for the use in vivo.

摘要

对肟K005[1,3-双(2-羟基亚氨基甲基吡啶鎓)丙烷二溴化物]进行了测试，它用于使被环沙林和VX抑制的乙酰胆碱酯酶(AChE)重新活化。与目前使用的AChE重新活化剂解磷定相比，其重新活化效力并不更好。另一方面，肟K005在10(-4)M的浓度下具有最大重新活化能力，这一浓度在人体使用中是可以达到的。解磷定在10(-1)M(对于环沙林)和10(-3)M(对于VX)的浓度下达到最大浓度，但这些浓度在体内使用时无法实现。

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