Sirot'áková Mária, Schmidtová Katarína, Kocisová Monika
University P. J. Safárik, Medical Faculty, Kosice, Slovak Republic: Institute of Experimental Medicine.
Acta Medica (Hradec Kralove). 2004;47(3):201-4.
Innervation of the spleen in rats was studied. Butyrylcholinesterase-(BuChE)-positive nerve components of the organ were visualized by the direct thiocholine method. BuChE-positive nerve components enter the spleen in a common bundle with arteries. In the organ they form characteristic periarterial and periarteriolar plexiform arrangements, which are especially conspicuous around the aa. centrales running through the white pulp. Then, nerve fibres extend away from these plexuses into adjacent layers of trabeculae further into marginal layers of periarterial lymphatic sheath (PALS) as well as into the mantle zone of follicles. Several scattered periarteriolar and solitary nerve fibres can be seen in the marginal sinuses and cords of the red pulp. In the fibrous capsula BuChE-positive nerve fibres can also be seen which have an evident connection with trabecular and parenchymal nerves of the organ. Microscopic findings support the notion that BuChE-positive nerve profiles supply not only the vasculature, but also the parenchymal components of the spleen, and they may participate, to a great extent, in the regulation of the immune processes in this organ.
对大鼠脾脏的神经支配进行了研究。通过直接硫代胆碱法观察到该器官中丁酰胆碱酯酶（BuChE）阳性神经成分。BuChE阳性神经成分与动脉以共同束的形式进入脾脏。在器官内，它们形成特征性的动脉周围和小动脉周围丛状排列，在穿过白髓的中央动脉周围尤为明显。然后，神经纤维从这些丛延伸到相邻的小梁层，进一步延伸到动脉周围淋巴鞘（PALS）的边缘层以及滤泡的套区。在红髓的边缘窦和索中可见几条散在的小动脉周围和孤立的神经纤维。在纤维囊中也可见到BuChE阳性神经纤维，它们与器官的小梁神经和实质神经有明显联系。显微镜检查结果支持这样的观点，即BuChE阳性神经分布不仅为脾脏的血管系统提供神经支配，也为脾脏的实质成分提供神经支配，并且它们可能在很大程度上参与该器官免疫过程的调节。
