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黑曲霉对川陈皮素的生物转化及一种代谢产物4'-羟基-5,6,7,8,3'-五甲氧基黄酮的抗诱变活性

Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.

作者信息

Okuno Yoshiharu, Miyazawa Mitsuo

机构信息

Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.

出版信息

J Nat Prod. 2004 Nov;67(11):1876-8. doi: 10.1021/np034007g.

DOI:10.1021/np034007g
PMID:15568779
Abstract

Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.

摘要

对黑曲霉对川陈皮素（1）的生物转化进行了研究，所得产物确定为4'-羟基-5,6,7,8,3'-五甲氧基黄酮（2）。发现化合物2具有抗诱变活性，它对由化学诱变剂呋喃糠酰胺、MeIQ和Trp-P-1诱导的鼠伤寒沙门氏菌TA1535/pSK1002中DNA损伤的SOS反应的umu基因表达具有抑制作用。

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