Miyazawa M, Okuno Y, Nakamura S i, Kosaka H
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.
J Agric Food Chem. 2000 Nov;48(11):5440-3. doi: 10.1021/jf0002544.
Suppression of the furylfuramide-induced SOS response by 25 kinds monoterpenoids (hydrocarbons, alcohols, ketones, and aldehydes) with a p-menthane skeleton was studied. Suppression of the SOS-inducing activity by monoterpenoids was determined in the umu test using Salmonella typhimurium TA1535/pSK1002. The terpene alcohols, ketones, and aldehydes had potent suppressive effects, but the hydrocarbons did not. Especially, (+)-menthol, (+)-pulegone, piperitenone, and cuminaldehyde were shown to have the most potent suppressive effects, and the ID(50) (dose for 50% inhibition) was 0.52 micromol/mL.
研究了25种具有对薄荷烷骨架的单萜类化合物（烃类、醇类、酮类和醛类）对糠基糠酰胺诱导的SOS反应的抑制作用。使用鼠伤寒沙门氏菌TA1535/pSK1002在umu试验中测定单萜类化合物对SOS诱导活性的抑制作用。萜烯醇类、酮类和醛类具有较强的抑制作用，而烃类则没有。特别是，（+）-薄荷醇、（+）-胡薄荷酮、胡椒酮和枯茗醛显示出最强的抑制作用，半数抑制剂量（ID50）为0.52微摩尔/毫升。
