• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

来自昆虫病原真菌蛹虫草BCC 2816的十元大环内酯类化合物。

10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816.

作者信息

Rukachaisirikul Vatcharin, Pramjit Songyos, Pakawatchai Chaveng, Isaka Masahiko, Supothina Sumalee

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.

出版信息

J Nat Prod. 2004 Nov;67(11):1953-5. doi: 10.1021/np0401415.

DOI:10.1021/np0401415
PMID:15568800
Abstract

Three new 10-membered macrolides (1-3) have been isolated from the entomopathogenic fungus Cordyceps militaris BCC 2816, together with six known compounds, cepharosporolides C (4), E (5), and F (6), 2-carboxymethyl-4-(3'-hydroxybutyl)furan (7), cordycepin (8), and pyridine-2,6-dicarboxylic acid. The structures were determined by analysis of NMR data, and an X-ray analysis was performed to confirm the structure of 1. The antimalarial activity of 1-4 and 8 against Plasmodium falciparum K1 was evaluated.

摘要

从昆虫病原真菌蛹虫草BCC 2816中分离出了三种新的十元大环内酯类化合物（1-3），以及六种已知化合物，即头孢菌素C（4）、E（5）和F（6）、2-羧甲基-4-（3'-羟基丁基）呋喃（7）、虫草素（8）和吡啶-2,6-二羧酸。通过核磁共振数据的分析确定了其结构，并进行了X射线分析以确认化合物1的结构。评估了化合物1-4和8对恶性疟原虫K1的抗疟活性。

相似文献

1
10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816.来自昆虫病原真菌蛹虫草BCC 2816的十元大环内酯类化合物。
J Nat Prod. 2004 Nov;67(11):1953-5. doi: 10.1021/np0401415.
2
A xanthocillin-like alkaloid from the insect pathogenic fungus Cordyceps brunnearubra BCC 1395.从昆虫病原真菌红褐虫草BCC 1395中分离得到的一种类黄青霉素生物碱。
J Nat Prod. 2007 Apr;70(4):656-8. doi: 10.1021/np060509t. Epub 2007 Feb 1.
3
Isolation and structure elucidation of a novel antimalarial macrocyclic polylactone, menisporopsin A, from the fungus Menisporopsis theobromae.从可可拟盘多毛孢真菌中分离并鉴定出一种新型抗疟大环多内酯——可可拟盘多毛孢菌素A。
J Nat Prod. 2004 Apr;67(4):689-92. doi: 10.1021/np0304870.
4
Cyclohexadepsipeptides from the insect pathogenic fungus Hirsutella nivea BCC 2594.来自昆虫病原真菌雪白丝穗霉BCC 2594的环己缩肽
J Nat Prod. 2005 Nov;68(11):1680-2. doi: 10.1021/np050246n.
5
Menisporopsin B, a new polyester from the seed fungus Menisporopsis theobromae BCC 4162.半月板孢菌素B，一种从可可豆种子真菌（Menisporopsis theobromae BCC 4162）中提取的新型聚酯。
J Antibiot (Tokyo). 2007 Dec;60(12):748-51. doi: 10.1038/ja.2007.98.
6
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.来自真菌孔状香菇BCC 8996的海松烷倍半萜类化合物。
J Nat Prod. 2005 Nov;68(11):1674-6. doi: 10.1021/np0502286.
7
Antimalarial benzoquinones from an endophytic fungus, Xylaria sp.来自内生真菌木层孔菌属（Xylaria sp.）的抗疟苯醌
J Nat Prod. 2007 Oct;70(10):1620-3. doi: 10.1021/np0701069. Epub 2007 Sep 25.
8
Paecilodepsipeptide A, an antimalarial and antitumor Cyclohexadepsipeptide from the insect pathogenic fungus Paecilomyces cinnamomeus BCC 9616.拟青霉环缩肽A，一种从昆虫病原真菌肉桂拟青霉BCC 9616中提取的具有抗疟和抗肿瘤活性的环己缩肽。
J Nat Prod. 2007 Apr;70(4):675-8. doi: 10.1021/np060602h. Epub 2007 Feb 2.
9
Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964.从虫生病原真菌 Aschersonia paraphysata BCC 11964 中分离得到的霍烷型三萜和联萘并吡喃酮。
J Nat Prod. 2010 Apr 23;73(4):688-92. doi: 10.1021/np1000363.
10
A cyclopeptide from the Insect pathogenic fungus Cordyceps sp. BCC 1788.一种来自昆虫病原真菌虫草菌BCC 1788的环肽。
J Nat Prod. 2006 Feb;69(2):305-7. doi: 10.1021/np050433l.

引用本文的文献

1
MACROLACTONES AND MACROLIDES FROM PLANT ENDOPHYTIC FUNGI, CHEMICAL SCAFFOLDS, BIOLOGICAL ACTIVITIES AND SPECTROSCOPY: A COMPREHENSIVE REVIEW.植物内生真菌产生的大环内酯类化合物：化学结构、生物活性及光谱学综合评述
Bull Pharm Sci. 2024 Jun;47(1):151-168. doi: 10.21608/bfsa.2023.224497.1834.
2
Steglich esterification: A versatile synthetic approach toward the synthesis of natural products, their analogues/derivatives.施陶丁格酯化反应：一种用于合成天然产物及其类似物/衍生物的通用合成方法。
Heliyon. 2023 Dec 9;10(1):e23416. doi: 10.1016/j.heliyon.2023.e23416. eCollection 2024 Jan 15.
3
Genomic Comparison of Two Species of with Other Genera in the Family Cordycipitaceae.
麦角菌科中两种与其他属的基因组比较。
J Fungi (Basel). 2023 Nov 27;9(12):1146. doi: 10.3390/jof9121146.
4
A Polyketide Cyclase That Forms Medium-Ring Lactones.一种形成中环内酯的聚酮合酶。
J Am Chem Soc. 2021 Jan 13;143(1):80-84. doi: 10.1021/jacs.0c11226. Epub 2020 Dec 22.
5
Secondary Metabolites and the Risks of and .次生代谢物与 和 的风险。
Molecules. 2019 Feb 13;24(4):664. doi: 10.3390/molecules24040664.
6
PTP1B Inhibitors from the Entomogenous Fungi Isaria fumosorosea.Isaria fumosorosea 来源的 PTP1B 抑制剂。
Molecules. 2017 Nov 24;22(12):2058. doi: 10.3390/molecules22122058.
7
Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin.虫草的药理及治疗潜力，特别提及虫草素
3 Biotech. 2014 Feb;4(1):1-12. doi: 10.1007/s13205-013-0121-9. Epub 2013 Feb 19.
8
Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis.从草酸青霉中分离得到的细胞毒 1,3-噻唑和 1,2,4-噻二唑生物碱：结构阐明和全合成。
Molecules. 2016 Feb 26;21(3):232. doi: 10.3390/molecules21030232.
9
A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris.人工培养的北虫草子实体中虫草素对蛋白激酶B的直接靶向抗炎活性。
Pharmacogn Mag. 2015 Jul-Sep;11(43):477-85. doi: 10.4103/0973-1296.160454.
10
Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory?冬虫夏草：一种传统中药以及另一种真菌治疗生物工厂？
Phytochemistry. 2008 May;69(7):1469-95. doi: 10.1016/j.phytochem.2008.01.027. Epub 2008 Mar 17.