El-Khayat Ehab Saad, Abouelela Mohamed E, Abdelhamid Reda Ahmad, Alorainy Mohammad S, Shaaban Khaled A
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Bull Pharm Sci. 2024 Jun;47(1):151-168. doi: 10.21608/bfsa.2023.224497.1834.
The pandemic of COVID-19 has stressed the exaggerated demand for innovative treatments, prompting the search for new sources. Plant endophytic fungi produce a diverse array of biologically active compounds, including macrolides and macrolactones with varying activities.
In this review we give an updated overview of natural macrolides and macrololactones from plant endophytes addressing original studies published up to June 2023.
Over the preceding ten years, 91 macrolides with 80 novel compounds with cytotoxic, antibacterial, antifungal, and α-glucosidase inhibitory activities. Unfortunately, the number of novel chemicals identified from marine or bacterial endophytes in the same period is substantially lower. Accordingly, further study on plant endophytes, which are critical for drug research and the development of novel medicines, including antitumors, antivirals, antibacterials, and antimalarials, should be conducted. A report of the C NMR data of several endophytic macrolides are reported as a supplementary according to ring sizes and based on a united numbering built on literature search.
2019冠状病毒病大流行凸显了对创新治疗方法的迫切需求，促使人们寻找新的来源。植物内生真菌产生多种生物活性化合物，包括具有不同活性的大环内酯类和大环内酯类化合物。
在本综述中，我们对截至2023年6月发表的有关植物内生菌天然大环内酯类和大环内酯类化合物的原始研究进行了更新概述。
在过去十年中，有91种大环内酯类化合物，其中80种为具有细胞毒性、抗菌、抗真菌和α-葡萄糖苷酶抑制活性的新化合物。遗憾的是，同期从海洋或细菌内生菌中鉴定出的新化学物质数量要少得多。因此，应进一步研究植物内生菌，其对药物研究和新型药物（包括抗肿瘤、抗病毒、抗菌和抗疟疾药物）的开发至关重要。根据环大小并基于文献检索建立的统一编号，补充报道了几种内生大环内酯类化合物的碳核磁共振数据。
