末期有丝分裂：Cdc14磷酸酶的功能及其调控

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.

作者信息

Stegmeier Frank, Amon Angelika

机构信息

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

出版信息

Annu Rev Genet. 2004;38:203-32. doi: 10.1146/annurev.genet.38.072902.093051.

DOI:10.1146/annurev.genet.38.072902.093051

PMID:15568976

Abstract

Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding yeast, the protein phosphatase Cdc14 is a key regulator of these late mitotic events. Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features.

摘要

细胞周期的完成需要染色体分离与有丝分裂纺锤体解体及胞质分裂在时间和空间上的协调。在芽殖酵母中，蛋白磷酸酶Cdc14是这些有丝分裂后期事件的关键调节因子。在此，我们综述Cdc14的功能以及该磷酸酶如何被调控以实现有丝分裂过程的偶联。我们还讨论了Cdc14在其他真核生物中的功能和调控，重点强调保守特征。