Wilder-Smith C H, Röhss K, Bondarov P, Hallerbäck B, Svedberg L-E, Ahlbom H
Gastroenterology Group Practice, GI Physiology Laboratory, Berne, Switzerland.
Aliment Pharmacol Ther. 2004 Nov 15;20(10):1099-104. doi: 10.1111/j.1365-2036.2004.02272.x.
Oral esomeprazole 40 mg provides greater acid control than oral pantoprazole 40 mg.
To compare the effects on intragastric acid control of esomeprazole 40 mg administered intravenously with pantoprazole 40 mg intravenously.
Healthy Helicobacter pylori-negative male and female subjects were enrolled into this single-centre, open, randomized, two-way crossover study. Esomeprazole 40 mg intravenously and pantoprazole 40 mg intravenously were administered as 15-min infusions once daily at 09:00 hours for 5 days. Continuous 24-h intragastric pH monitoring was carried out at baseline and on days 1 and 5.
pH-data were available for all 25 subjects who completed the study. Esomeprazole 40 mg intravenously resulted in 8.3 and 13.9 h with an intragastric pH > 4 on days 1 and 5 compared with 5.3 and 9.0 h, respectively for pantoprazole 40 mg intravenously (day 1: P < 0.001, day 5: P < 0.0001). During the first 4 h of dosing on day 1 corresponding values were 1.7 and 0.6 h respectively (P < 0.0001). A mean median pH above 4 on day 5 was only attained with esomeprazole 40 mg intravenously.
Once-daily dosing with esomeprazole 40 mg intravenously provides faster and more pronounced intragastric acid control than pantoprazole 40 mg intravenously.
口服40毫克埃索美拉唑比口服40毫克泮托拉唑能更好地控制胃酸。
比较静脉注射40毫克埃索美拉唑和静脉注射40毫克泮托拉唑对胃内胃酸控制的效果。
健康的幽门螺杆菌阴性的男性和女性受试者被纳入这项单中心、开放、随机、双向交叉研究。静脉注射40毫克埃索美拉唑和静脉注射40毫克泮托拉唑均于每日09:00时作为15分钟输注给药，持续5天。在基线以及第1天和第5天进行连续24小时胃内pH监测。
所有25名完成研究的受试者均有pH数据。静脉注射40毫克埃索美拉唑在第1天和第5天胃内pH>4的时间分别为8.3小时和13.9小时，而静脉注射40毫克泮托拉唑分别为5.3小时和9.0小时（第1天：P<0.001，第5天：P<0.0001）。在第1天给药的前4小时，相应的值分别为1.7小时和0.6小时（P<0.0001）。仅静脉注射40毫克埃索美拉唑在第5天达到了平均中位pH高于4。
每日一次静脉注射40毫克埃索美拉唑比静脉注射40毫克泮托拉唑能更快、更显著地控制胃内胃酸。
