Walsh Stewart R, Gladwish Kelly M, Ward Nicholas J, Justin Timothy A, Keeling Neil J
Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, Hardwick Lane, Bury St Edmunds, Suffolk IP32 7TG, United Kingdom.
World J Surg Oncol. 2004 Nov 29;2:40. doi: 10.1186/1477-7819-2-40.
Survival in colorectal cancer may correlate with the degree of systemic inflammatory response to the tumour. Atrial fibrillation may be regarded as an inflammatory complication. We aimed to determine if atrial fibrillation is a prognostic factor in colorectal cancer.
A prospective colorectal cancer patient database was cross-referenced with the hospital clinical-coding database to identify patients who had underwent colorectal cancer surgery and were in atrial fibrillation pre- or postoperatively.
A total of 175 patients underwent surgery for colorectal cancer over a two-year period. Of these, 13 patients had atrial fibrillation pre- or postoperatively. Atrial fibrillation correlated with worse two-year survival (p = 0.04; log-rank test). However, in a Cox regression analysis, atrial fibrillation was not significantly associated with survival.
The presence or development of atrial fibrillation in patients undergoing surgery for colorectal cancer is associated with worse overall survival, however it was not found to be an independent factor in multivariate analysis.
结直肠癌患者的生存情况可能与机体对肿瘤的全身炎症反应程度相关。心房颤动可被视为一种炎症并发症。我们旨在确定心房颤动是否为结直肠癌的一个预后因素。
将一个前瞻性结直肠癌患者数据库与医院临床编码数据库进行交叉对照，以识别接受过结直肠癌手术且术前或术后处于心房颤动状态的患者。
在两年期间，共有175例患者接受了结直肠癌手术。其中，13例患者术前或术后出现心房颤动。心房颤动与较差的两年生存率相关（p = 0.04；对数秩检验）。然而，在Cox回归分析中，心房颤动与生存率无显著相关性。
接受结直肠癌手术的患者出现心房颤动或发生心房颤动与总体生存率较差相关，但在多变量分析中未发现其为独立因素。
