Michel-Briand Y, Nicolas T, Godard C, Plesiat P
Laboratoire de Bactériologie, URA 531, Faculté de Médecine, Besançon, France.
Microbiologica. 1992 Jan;15(1):65-9.
4.2% Pseudomonas aeruginosa strains isolated in our hospital were resistant to ceftazidime. The 174K strain was also resistant to azthreonam but susceptible to imipenem and was studied as representative of these strains. It produced a single beta-lactamase (pI 8.6) which had all the characteristics of the chromosomal beta-lactamase Id and was the only beta-lactamase present. This enzyme hydrolyses slowly ceftazidime and imipenem. It could be a factor of imipenem resistance if the antibiotic influx into the bacteria was decreased or if the beta-lactamase Id was synthesized at a high level.
我院分离出的铜绿假单胞菌菌株中有4.2%对头孢他啶耐药。174K菌株对氨曲南也耐药，但对亚胺培南敏感，作为这些菌株的代表进行了研究。它产生一种单一的β-内酰胺酶（pI 8.6），具有染色体β-内酰胺酶Id的所有特征，并且是唯一存在的β-内酰胺酶。这种酶对头孢他啶和亚胺培南的水解作用缓慢。如果抗生素进入细菌的量减少，或者β-内酰胺酶Id高水平合成，它可能是亚胺培南耐药的一个因素。
